Locked and Unlocked Nucleosides in Functional Nucleic Acids

Locked and unlocked nucleosides in functional nucleic acids.

Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in fun...

Nucleosides, Nucleotides and Nucleic Acids

To cite this article: Krzysztof Komodziński, Zofia Gdaniec & Bohdan Skalski (2015) Photochemical Behavior of 2-Azidopurine Tri-O-Acetylribonucleoside in Aqueous Solution: Unprecedented Transformation into 1-(5′-O-Acetyl-β-D-Ribofuranosyl)-5-[(2-Oxo-1,3,5Oxadiazocan-4-Ylidene)Amino]-1H-Imidazole-4-Carbaldehyde, Nucleosides, Nucleotides and Nucleic Acids, 34:4, 235-245, DOI: 10.1080/15257770.2014...

Nucleosides, Nucleotides and Nucleic Acids

Drug–DNA Interaction Studies of Acridone-Based Derivatives Kuntebomanahalli Thimmaiah, Apoorva G. Ugarkar, Elvis F. Martis, Mushtaque S. Shaikh, Evans C. Coutinho & Mayur C. Yergeri To cite this article: Kuntebomanahalli Thimmaiah, Apoorva G. Ugarkar, Elvis F. Martis, Mushtaque S. Shaikh, Evans C. Coutinho & Mayur C. Yergeri (2015) Drug–DNA Interaction Studies of Acridone-Based Derivatives, Nuc...

Nucleosides, Nucleotides and Nucleic Acids

Locked Nucleic Acids (LNAs)

With few exceptions, experimental success in molecular biology is dependent upon specific, discriminating, and persistent hybridization events involving synthetic oligonucleotides and their complementary target sequences. While unmodified oligodeoxynucleotides will routinely form desired DNA:DNA and DNA:RNA duplexes, synthesis of various modifications that confer enhanced high-affinity recognit...